Oyinkansola Funmilayo Olowoyo & Oyewale Olukorede Afuye

Diabetes mellitus is a chronic metabolic condition that results from absence of insulin secretion or activity (Kumar et al., 2011). The number of instances and prevalence of diabetes have gradually increased over the last decenary, and it is recognized as a quiet killer illness, impacting millions of people worldwide (Onyenibe and Udogadi, 2019). The vast majority of medicinal plants are used by inhibiting the enzymes involved in carbohydrates metabolism to treat diabetes and they mostly act, example of such is Bridelia ferruginea, but there is the need for improved activities of these plants in the body for better effects. Nanoparticle has recently been used to increase the effectiveness of bioactive compounds in plants. MgONPs were prepared using 150 ml of the freshly prepared 5mM Magnesium nitrate solution and 30ml of Bridelia ferruginea aqueous extract. Scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR) were used to characterize the nanoparticles. MgO nanoparticles was obtained after several hours from brown to pale yellow. The SEM images of biosynthesized MgO nanopartcles of Bridelia ferruginea (MgONPs-Bf) aqueous extract leave in this study are agglomerated and FTIR showed that carbonyl groups contributed to MgONPs-Bf synthesis. At increasing concentration of 20,40,60,80 and 100 µg/ml of Bridelia ferruginea the inhibitory capacity against α-amylase and α-glucosidase increased (51.82±0.52, 64.45±0.58, 74.15±0.49, 81.08±0.17, 88.08±0.12 and 46.48±0.078, 51.72±0.028, 58.99±0.170, 67.75±0.247, 83.08±0.170) as compared to acarbose. Bridelia ferruginea might aid in the development of MgONPs with considerably better pharmacokinetic characteristics and therapeutic performance in hyperglycemia. Keywords: Nanomaterials; Bridelia ferruginea; Diabetes mellitus; hyperglycemia; α-amylase; α-glucosidase0150