Temitayo Adesipe

In low- and middle-income nations, many essential medicines remain out of reach and unaffordable, creating room for opportunists to wreak havoc. In sub-Saharan Africa alone, about 267,000 deaths per annum are usually linked to falsified and substandard drugs. The current study therefore evaluated the phytochemical constituents as well as the anti-inflammatory property of ethanol extracts of Egyptian Crowfoot Grass and its effect on the level of Glutathione (GSH) in rats using established protocols. The phytochemical screening revealed that the extract contained phytochemicals such as flavonoid, tannins, phenol, alkaloids, reducing sugar, and cardiac glycosides steroids and terpernoid. Acute toxicity test revealed that the oral administration (up to 2000 mg/kg b.w) of studied plant ethanol extract did not cause any physical toxicological effects in rats. The anti inflammatory result revealed that different concentrations (200 and 400 mg/kg b.w.) of ethanol extract of Egyptian Crowfoot Grass significantly reduced cellular infiltration to the inflammatory region and showed anti-inflammatory action in rats' paw inflammation. Significant alteration was also observed in GSH antioxidant enzyme level of the paw tissue homogenate of rats treated with the test plant. These results revealed that ethanol extract of Egyptian crowfoot grass can be used as a replacement for anti-inflammatory drugs. KEYWORDS: Egyptian Crowfoot Grass, Ethanol extract, Phytochemicals, Invivo antiinflammation  0150